Publications
2021 2020 2019 2018 2017 2016 2015 2014 2013 2012
2021
Molecular basis of human ATM kinase inhibition
Stakyte K*, Rotheneder M*, Lammens K, Bartho JD, Grädler U, Fuchß T, Pehl U, Alt A, van de Logt E and Hopfner KP. *equal contribution
Nat Struct Mol Biol. 2021 Sep 23. doi: 10.1038/s41594-021-00654-x. PubMed
BusR senses bipartite DNA binding motifs by a unique molecular ruler architecture.
Bandera AM, Bartho J, Lammens K, Drexler DJ, Kleinschwärzer J, Hopfner KP, Witte G.
Nucleic Acids Res. 2021 Sep 27;49(17):10166-10177. doi: 10.1093/nar/gkab736. PubMed
Site-Specific Antibody Fragment Conjugates for Reversible Staining in Fluorescence Microscopy.
Schwach J, Kolobynina K, Brandstetter K, Gerlach M, Ochtrop P, Helma J, Hackenberger CPR, Harz H, Cardoso MC, Leonhardt H, Stengl A.
Chembiochem. 2021 Apr 6;22(7):1205-1209. doi: 10.1002/cbic.202000727. PubMed
Solid state NMR assignments of a human λ-III immunoglobulin light chain amyloid fibril.
Pradhan T, Annamalai K, Sarkar R, Hegenbart U, Schönland S, Fändrich M, Reif B (2021)
Biomolecular NMR assignment 15: 9-16. PubMed
HP1β carries an acidic linker domain and requires H3K9me3 for phase separation.
Qin W, Stengl A, Ugur E, Leidescher S, Ryan J, Cardoso MC, Leonhardt H. (2021)
Nucleus. 12(1):44-57. PubMed
Comparative analysis of the coordinated motion of Hsp70s from different organelles observed by single-molecule three-color FRET.
Voith von Voithenberg L, Barth A, Trauschke V, Demarco B, Tyagi S, Koehler C, Lemke EA, Lamb DC (2021)
Proc Natl Acad Sci U S A. 118(33):e2025578118. PubMed
Identification and correction of miscalibration artifacts based on force noise for optical tweezers experiments.
Freitag M, Kamp D, Synakewicz M, Stigler J (2021)
J. Chem. Phys. 155, 175101. PubMed
Competitive Microtubule Binding of PEX14 Coordinates Peroxisomal Protein Import and Motility.
Reuter M, Kooshapur H, Suda JG, Gaussmann S, Neuhaus A, Brühl L, Bharti P, Jung M, Schliebs W, Sattler M, Erdmann R (2021)
J Mol Biol 433: 166765. PubMed
Loss-of-function mutations in the histone methyltransferase EZH2 promote chemotherapy resistance in AML.
Kempf JM, Weser S, Bartoschek MD, Metzeler KH, Vick B, Herold T, Völse K, Mattes R, Scholz M, Wange LE, Festini M, Ugur E, Roas M, Weigert O, Bultmann S, Leonhardt H, Schotta G, Hiddemann W, Jeremias I, Spiekermann K.
Sci Rep. 2021 Mar 12;11(1):5838. doi: 10.1038/s41598-021-84708-6. PubMed
2020
Structural basis of the (in)activity of the apical DNA damage response kinases ATM, ATR and DNA-PKcs.
Jansma M, Hopfner KP.
Prog Biophys Mol Biol. 2020 Nov 7:S0079-6107(20)30114-0. doi: 10.1016/j.pbiomolbio.2020.10.009. PubMed
C-Terminal Motifs of the MTW1 Complex Cooperatively Stabilize Outer Kinetochore Assembly in Budding Yeast
Ghodgaonkar-Steger M, Potocnjak M, Zimniak T, Fischböck-Halwachs J, Solis-Mezarino V, Singh S, Speljko T, Hagemann G, Drexler DJ, Witte G, Herzog F.
Cell Rep. 2020 Sep 29;32(13):108190. doi: 10.1016/j.celrep.2020.108190. PubMed
Structural basis for sequestration and autoinhibition of cGAS by chromatin.
Michalski S, de Oliveira Mann CC, Stafford C, Witte G, Bartho J, Lammens K, Hornung V, Hopfner KP.
Nature. 2020 Sep 10. doi: 10.1038/s41586-020-2748-0. PubMed
Structural insights into the nucleic acid remodeling mechanisms of the yeast THO-Sub2 complex.
Schuller SK, Schuller JM, Prabu JR, Baumgärtner M, Bonneau F, Basquin J, Conti E (2020)
Elife 9 PubMed
An autoinhibitory intramolecular interaction proof-reads RNA recognition by the essential splicing factor U2AF2.
Kang HS, Sánchez-Rico C, Ebersberger S, Sutandy FXR, Busch A, Welte T, Stehle R, Hipp C, Schulz L, Buchbender A, Zarnack K, König J, Sattler M (2020)
Proc Natl Acad Sci U S A 117: 7140-7149 PubMed
Structure and function of yeast Lso2 and human CCDC124 bound to hibernating ribosomes.
Wells JN, Buschauer R, Mackens-Kiani T, Best K, Kratzat H, Berninghausen O, Becker T, Gilbert W, Cheng J, Beckmann R.
PLoS Biol. 2020;18(7):e3000780. PubMed
EDF1 coordinates cellular responses to ribosome collisions.
Sinha NK, Ordureau A, Best K, Saba JA, Zinshteyn B, Sundaramoorthy E, Fulzele A, Garshott DM, Denk T, Thoms M, Paulo JA, Harper JW, Bennett EJ, Beckmann R, Green R.
Elife. 2020 Aug 3;9:e58828. doi: 10.7554/eLife.58828. PubMed
Sortase-Mediated Quantifiable Enzyme Immobilization on Magnetic Nanoparticles.
Fauser J, Savitskiy S, Fottner M, Trauschke V, Gulen B.
Bioconjug Chem. 2020 Jul 10. doi: 10.1021/acs.bioconjchem.0c00322. Online ahead of print. PubMed
Distinct and stage-specific contributions of TET1 and TET2 to stepwise cytosine oxidation in the transition from naive to primed pluripotency.
Mulholland CB, Traube FR, Ugur E, Parsa E, Eckl EM, Schönung M, Modic M, Bartoschek MD, Stolz P, Ryan J, Carell T, Leonhardt H, Bultmann S.
Sci Rep. 2020 Jul 21;10(1):12066. doi: 10.1038/s41598-020-68600-3. PubMed
Auto-inhibition of Mif2/CENP-C ensures centromere-dependent kinetochore assembly in budding yeast.
Killinger K, Böhm M, Steinbach P, Hagemann G, Blüggel M, Jänen K, Hohoff S, Bayer P, Herzog F, Westermann S.
EMBO J. 2020 Jul 15;39(14):e102938. doi: 10.15252/embj.2019102938. PubMed
Structure of substrate-bound SMG1-8-9 kinase complex reveals molecular basis for phosphorylation specificity.
Langer LM, Gat Y, Bonneau F, Conti E.
Elife. 2020 May 29;9:e57127. doi: 10.7554/eLife.57127. Online ahead of print. PubMed
Locus-Specific Chromatin Proteome Revealed by Mass Spectrometry-Based CasID.
Ugur E, Bartoschek MD, Leonhardt H.
Methods Mol Biol. 2020;2175:109-121. doi: 10.1007/978-1-0716-0763-3_9. PubMed
Recent evolution of a TET-controlled and DPPA3/STELLA-driven pathway of passive DNA demethylation in mammals.
Mulholland CB, Nishiyama A, Ryan J, Nakamura R, Yiğit M, Glück IM, Trummer C, Qin W, Bartoschek MD, Traube FR, Parsa E, Ugur E, Modic M, Acharya A, Stolz P, Ziegenhain C, Wierer M, Enard W, Carell T, Lamb DC, Takeda H, Nakanishi M, Bultmann S, Leonhardt H. (2020)
Nat Commun. 11(1):5972. PubMed
Seeded fibrils of the germline variant of human λ-III immunoglobulin light chain FOR005 have a similar core as patient fibrils with reduced stability.
Pradhan T, Annamalai K, Sarkar R, Huhn S, Hegenbart U, Schönland S, Fändrich M, Reif B (2020)
J Biol Chem 295: 18474-18484 PubMed
Systematic analysis of the binding behaviour of UHRF1 towards different methyl- and carboxylcytosine modification patterns at CpG dyads.
Schneider M, Trummer C, Stengl A, Zhang P, Szwagierczak A, Cardoso MC, Leonhardt H, Bauer C, Antes I.
PLoS One. 2020 Feb 21;15(2):e0229144. doi: 10.1371/journal.pone.0229144. eCollection 2020. PubMed
c-di-AMP hydrolysis by the phosphodiesterase AtaC promotes differentiation of multicellular bacteria.
Latoscha A, Drexler DJ, Al-Bassam MM, Bandera AM, Kaever V, Findlay KC, Witte G, Tschowri N.
Proc Natl Acad Sci U S A. 2020 Mar 18. pii: 201917080. doi: 10.1073/pnas.1917080117. PubMed
Near-Complete Structure and Model of Tel1ATM from Chaetomium thermophilum Reveals a Robust Autoinhibited ATP State.
Jansma M, Linke-Winnebeck C, Eustermann S, Lammens K, Kostrewa D, Stakyte K, Litz C, Kessler B, Hopfner KP.
Structure. 2020 Jan 7;28(1):83-95.e5. doi: 10.1016/j.str.2019.10.013. PubMed
2019
Cysteine-Selective Phosphonamidate Electrophiles for Modular Protein Bioconjugations.
Kasper MA, Glanz M, Stengl A, Penkert M, Klenk S, Sauer T, Schumacher D, Helma J, Krause E, Cardoso MC, Leonhardt H, Hackenberger CPR.
Angew Chem Int Ed Engl. 2019 Aug 19;58(34):11625-11630. doi: 10.1002/anie.201814715. PubMed
Restriction of AID activity and somatic hypermutation by PARP-1.
Tepper S, Mortusewicz O, Członka E, Bello A, Schmidt A, Jeschke J, Fischbach A, Pfeil I, Petersen-Mahrt SK, Mangerich A, Helleday T, Leonhardt H, Jungnickel B.
Nucleic Acids Res. 2019 Aug 22;47(14):7418-7429. doi: 10.1093/nar/gkz466. PubMed
Structural and mutational analysis of the ribosome-arresting human XBP1u.
Shanmuganathan V, Schiller N, Magoulopoulou A, Cheng J, Braunger K, Cymer F, Berninghausen O, Beatrix B, Kohno K, Heijne GV, Beckmann R.
Elife. 2019 Jun 27;8. pii: e46267. doi: 10.7554/eLife.46267. PubMed
TuPPL: Tub-tag mediated C-terminal protein-protein-ligation using complementary click-chemistry handles.
Stengl A, Gerlach M, Kasper MA, Hackenberger CPR, Leonhardt H, Schumacher D, Helma J.
Org Biomol Chem. 2019 May 28;17(20):4964-4969. doi: 10.1039/c9ob00508k. PubMed
Combinatorial recognition of clustered RNA elements by the multidomain RNA-binding protein IMP3.
Schneider T, Hung LH, Aziz M, Wilmen A, Thaum 1, Wagner J, Janowski R, Müller S, Schreiner S, Friedhoff P, Hüttelmaier S, Niessing D, Sattler M, Schlundt A, Bindereif A.
Nat Commun. 2019 May 22;10(1):2266. doi: 10.1038/s41467-019-09769-8. PubMed
Selective Inhibitors of FKBP51 Employ Conformational Selection of Dynamic Invisible States.
Jagtap PKA, Asami S, Sippel C, Kaila VRI, Hausch F, Sattler M (2019)
Angew Chem Int Ed Engl 58: 9429-9433
The MTR4 helicase recruits nuclear adaptors of the human RNA exosome using distinct arch-interacting motifs.
Lingaraju M, Johnsen D, Schlundt A, Langer LM, Basquin J, Sattler M, Heick Jensen T, Falk S, Conti E (2019a)
Nat commun. 10: 3393
To Process or to Decay: A Mechanistic View of the Nuclear RNA Exosome.
Lingaraju M, Schuller JM, Falk S, Gerlach P, Bonneau F, Basquin J, Benda C, Conti E (2019b)
Cold Spring Harb Symp Quant Biol 84: 155-163
Mechanism of DNA End Sensing and Processing by the Mre11-Rad50 Complex.
Käshammer L, Saathoff JH, Lammens K, Gut F, Bartho J, Alt A, Kessler B, Hopfner KP (2019).
Mol Cell 76:382-394.
Molecular Basis for poly(A) RNP Architecture and Recognition by the Pan2-Pan3 Deadenylase.
Schäfer IB, Yamashita M, Schuller JM, Schüssler S, Reichelt P, Strauss M, Conti E (2019)
Cell 177: 1619-1631.e21
The structure and oxidation of the eye lens chaperone αA-crystallin.
Kaiser CJO, Peters C, Schmid PWN, Stavropoulou M, Zou J, Dahiya V, Mymrikov EV, Rockel B, Asami S, Haslbeck M, Rappsilber J, Reif B, Zacharias M, Buchner J, Weinkauf S. (2019)
Nat Struct Mol Biol. (12):1141-1150
Photo-induced and Rapid Labeling of Tetrazine-Bearing Proteins via Cyclopropenone-Caged Bicyclononynes.
Mayer SV, Murnauer A, von Wrisberg MK, Jokisch ML, Lang K (2019)
Angew Chem Int Ed Engl 58: 15876-15882
Structural adaptations of photosynthetic complex I enable ferredoxin-dependent electron transfer.
Schuller JM, Birrell JA, Tanaka H, Konuma T, Wulfhorst H, Cox N, Schuller SK, Thiemann J, Lubitz W, Sétif P, Ikegami T, Engel BD, Kurisu G, Nowaczyk MM (2019)
Science. 363(6424):257-260.
InsP(6) binding to PIKK kinases revealed by the cryo-EM structure of an SMG1-SMG8-SMG9 complex.
Gat Y, Schuller JM, Lingaraju M, Weyher E, Bonneau F, Strauss M, Murray PJ, Conti E (2019)
Nat Struct Mol Biol 26: 1089-1093
Staufen2-mediated RNA recognition and localization requires combinatorial action of multiple domains.
Heber S, Gáspár I, Tants JN, Günther J, Moya SMF, Janowski R, Ephrussi A, Sattler M, Niessing D (2019)
Nat commun 10: 1659
The COMA complex interacts with Cse4 and positions Sli15/Ipl1 at the budding yeast inner kinetochore.
Fischböck-Halwachs J, Singh S, Potocnjak M, Hagemann G, Solis-Mezarino V, Woike S, Ghodgaonkar-Steger M, Weissmann F, Gallego LD, Rojas J, Andreani J, Köhler A, Herzog F.
Elife. 2019 May 21;8. pii: e42879. doi: 10.7554/eLife.42879. PubMed
Site-specific ubiquitylation and SUMOylation using genetic-code expansion and sortase.
Fottner M, Brunner AD, Bittl V, Horn-Ghetko D, Jussupow A, Kaila VRI, Bremm A, Lang K.
Nat Chem Biol. 2019 Mar;15(3):276-284. doi: 10.1038/s41589-019-0227-4. PubMed
FLEXamers: A Double Tag for Universal Generation of Versatile Peptide-MHC Multimers.
Effenberger M, Stengl A, Schober K, Gerget M, Kampick M, Müller TR, Schumacher D, Helma J, Leonhardt H, Busch DH.
J Immunol. 2019 Feb 13. pii: ji1801435. doi: 10.4049/jimmunol.1801435. PubMed
A conserved filamentous assembly underlies the structure of the meiotic chromosome axis.
West AMV, Rosenberg SC, Ur SN, Lehmer MK, Ye Q, Hagemann G, Caballero I, Uson I, MacQueen AJ, Herzog F, Corbett KD.
Elife. 2019 Jan 18;8. pii: e40372. doi: 10.7554/eLife.40372. PubMed
2018
A Click-Chemistry Linked 2'3'-cGAMP Analog.
Dialer CR, Stazzoni S, Drexler DJ, Müller FM, Veth S, Pichler A, Okamura H, Witte G, Hopfner KP, Carell T.
Chemistry. 2018 Dec 10. doi: 10.1002/chem.201805409. PubMed
A single residue switch reveals principles of antibody domain integrity.
Weber B, Brandl MJ, Pulido Cendales MD, Berner C, Pradhan T, Feind GM, Zacharias M, Reif B, Buchner J.
J Biol Chem. 2018 Nov 2;293(44):17107-17118. doi: 10.1074/jbc.RA118.005475. PubMed
Direct induction of microtubule branching by microtubule nucleation factor SSNA1.
Basnet N, Nedozralova H, Crevenna AH, Bodakuntla S, Schlichthaerle T, Taschner M, Cardone G, Janke C, Jungmann R, Magiera MM, Biertümpfel C, Mizuno N.
Nat Cell Biol. 2018 Oct;20(10):1172-1180. doi: 10.1038/s41556-018-0199-8. Epub 2018 Sep 24. PubMed
Crystal structure of the full Swi2/Snf2 remodeler Mot1 in the resting state.
Butryn A, Woike S, Shetty SJ, Auble DT, Hopfner KP.
Elife. 2018 Oct 5;7. pii: e37774. doi: 10.7554/eLife.37774. PubMed
The nuclear actin-containing Arp8 module is a linker DNA sensor driving INO80 chromatin remodeling.
Knoll KR, Eustermann S, Niebauer V, Oberbeckmann E, Stoehr G, Schall K, Tosi A, Schwarz M, Buchfellner A, Korber P & Hopfner KP.
Nature Structural & Molecular Biology. 2018 Sept 3. doi: 10.1038/s41594-018-0115-8. PubMed
Structural basis for coupling protein transport and N-glycosylation at the mammalian endoplasmic reticulum.
Braunger K, Pfeffer S, Shrimal S, Gilmore R, Berninghausen O, Mandon EC, Becker T, Förster F, Beckmann R.
Science. 2018 Mar 8. pii: eaar7899. doi: 10.1126/science.aar7899. PubMed
Ultrashort Broadband Cooperative Pulses for Multidimensional Biomolecular NMR Experiments.
Asami S, Kallies W, Günther JC, Stavropoulou M, Glaser SJ, Sattler M.
Angew Chem Int Ed Engl. 2018 Mar 5. doi: 10.1002/anie.201800220. PubMed
Distinct and evolutionary conserved structural features of the human nuclear exosome complex.
Gerlach P, Schuller JM, Bonneau F, Basquin J, Reichelt P, Falk S, Conti E (2018)
Elife 7
Structural basis for terminal loop recognition and stimulation of pri-miRNA-18a processing by hnRNP A1.
Kooshapur H, Choudhury NR, Simon B, Mühlbauer M, Jussupow A, Fernandez N, Jones AN, Dallmann A, Gabel F, Camilloni C, Michlewski G, Caceres JF, Sattler M (2018)
Nat commun. 9: 2479
Expanding the Genetic Code to Study Protein-Protein Interactions.
Nguyen TA, Cigler M, Lang K (2018)
Angew Chem Int Ed Engl 57: 14350-14361
The bacterial Mre11-Rad50 homolog SbcCD cleaves opposing strands of DNA by two chemically distinct nuclease reactions.
Saathoff JH, Käshammer L, Lammens K, Byrne RT, Hopfner KP (2018).
Nucleic Acids Res 46:11303-11314.
Structure of the nuclear exosome captured on a maturing preribosome.
Schuller JM, Falk S, Fromm L, Hurt E, Conti E (2018)
Science 360: 219-222
A single residue switch reveals principles of antibody domain integrity.
Weber B, Brandl MJ, Pulido Cendales MD, Berner C, Pradhan T, Feind GM, Zacharias M, Reif B, Buchner J (2018)
J Biol Chem 293: 17107-17118
2017
Visualizing the Assembly Pathway of Nucleolar Pre-60S Ribosomes.
Kater L, Thoms M, Barrio-Garcia C, Cheng J, Ismail S, Ahmed YL, Bange G, Kressler D, Berninghausen O, Sinning I, Hurt E, Beckmann R.
Cell. 2017 Dec 14;171(7):1599-1610.e14. doi: 10.1016/j.cell.2017.11.039. PubMed
Preribosomes escaping from the nucleus are caught during translation by cytoplasmic quality control.
Sarkar A, Thoms M, Barrio-Garcia C, Thomson E, Flemming D, Beckmann R, Hurt E.
Nat Struct Mol Biol. 2017 Dec;24(12):1107-1115. doi: 10.1038/nsmb.3495. Epub 2017 Oct 30. PubMed
Structural and Biophysical Analysis of the Soluble DHH/DHHA1-Type Phosphodiesterase TM1595 from Thermotoga maritima.
Drexler DJ, Müller M, Rojas-Cordova CA, Bandera AM, Witte G.
Structure. 2017 Dec 5;25(12):1887-1897.e4. doi: 10.1016/j.str.2017.10.001. Epub 2017 Oct 26. PubMed
Proximity-Triggered Covalent Stabilization of Low-Affinity Protein Complexes In Vitro and In Vivo.
Cigler M, Müller TG, Horn-Ghetko D, von Wrisberg MK, Fottner M, Goody RS, Itzen A, Müller MP, Lang K.
Angew Chem Int Ed Engl. 2017 Dec 4;56(49):15737-15741. doi: 10.1002/anie.201706927. Epub 2017 Nov 9. PubMed
Mechanistic insight into the assembly of the HerA-NurA helicase-nuclease DNA end resection complex.
Ahdash Z, Lau AM, Byrne RT, Lammens K, Stüetzer A, Urlaub H, Booth PJ, Reading E, Hopfner KP, Politis A (2017).
Nucleic Acids Res 45:12025-12038 PubMed
Kindlin-2 recruits paxillin and Arp2/3 to promote membrane protrusions during initial cell spreading.
Böttcher RT, Veelders M, Rombaut P, Faix J, Theodosiou M, Stradal TE, Rottner K, Zent R, Herzog F, Fässler R.
J Cell Biol. 2017 Nov 6;216(11):3785-3798. doi: 10.1083/jcb.201701176. Epub 2017 Sep 14. PubMed
Segmental, Domain-Selective Perdeuteration and Small-Angle Neutron Scattering for Structural Analysis of Multi-Domain Proteins.
Sonntag M, Jagtap PKA, Simon B, Appavou MS, Geerlof A, Stehle R, Gabel F, Hennig J, Sattler M.
Angew Chem Int Ed Engl. 2017 Aug 1;56(32):9322-9325. doi: 10.1002/anie.201702904. Epub 2017 Jul 5. PubMed
RNA structure refinement using NMR solvent accessibility data.
Hartlmüller C, Günther JC, Wolter AC, Wöhnert J, Sattler M, Madl T.
Sci Rep. 2017 Jul 14;7(1):5393. doi: 10.1038/s41598-017-05821-z. PubMed
Effects of Fluorophore Attachment on Protein Conformation and Dynamics Studied by spFRET and NMR Spectroscopy.
Sánchez-Rico C, Voith von Voithenberg L, Warner L, Lamb DC, Sattler M.
Chemistry. 2017 Oct 12;23(57):14267-14277. doi: 10.1002/chem.201702423. Epub 2017 Sep 12. PubMed
Cryo-EM structure of a late pre-40S ribosomal subunit from Saccharomyces cerevisiae.
Heuer A, Thomson E, Schmidt C, Berninghausen O, Becker T, Hurt E, Beckmann R.
Elife. 2017 Nov 20;6. pii: e30189. doi: 10.7554/eLife.30189. PubMed
Structural Basis for Polyproline-Mediated Ribosome Stalling and Rescue by the Translation Elongation Factor EF-P.
Huter P, Arenz S, Bock LV, Graf M, Frister JO, Heuer A, Peil L, Starosta AL, Wohlgemuth I, Peske F, Nováček J, Berninghausen O, Grubmüller H, Tenson T, Beckmann R, Rodnina MV, Vaiana AC, Wilson DN.
Mol Cell. 2017 Nov 2;68(3):515-527.e6. doi: 10.1016/j.molcel.2017.10.014. PubMed
cGAS senses long and HMGB/TFAM-bound U-turn DNA by forming protein-DNA ladders.
Andreeva L, Hiller B, Kostrewa D, Lässig C, de Oliveira Mann CC, Jan Drexler D, Maiser A, Gaidt M, Leonhardt H, Hornung V, Hopfner KP.
Nature. 2017 Sep 21;549(7672):394-398. doi: 10.1038/nature23890. Epub 2017 Sep 13. PubMed
Structure of the Bacillus subtilis hibernating 100S ribosome reveals the basis for 70S dimerization.
Beckert B, Abdelshahid M, Schäfer H, Steinchen W, Arenz S, Berninghausen O, Beckmann R, Bange G, Turgay K, Wilson DN.
EMBO J. 2017 May 3. pii: e201696189. doi: 10.15252/embj.201696189. PubMed
Structure of the 40S-ABCE1 post-splitting complex in ribosome recycling and translation initiation.
Heuer A, Gerovac M, Schmidt C, Trowitzsch S, Preis A, Kötter P, Berninghausen O, Becker T, Beckmann R, Tampé R.
Nat Struct Mol Biol. 2017 May;24(5):453-460. doi: 10.1038/nsmb.3396. Epub 2017 Apr 3. PubMed
Structure of the RZZ complex and molecular basis of its interaction with Spindly.
Mosalaganti S, Keller J, Altenfeld A, Winzker M, Rombaut P, Saur M, Petrovic A, Wehenkel A, Wohlgemuth S, Müller F, Maffini S, Bange T, Herzog F, Waldmann H, Raunser S, Musacchio A.
J Cell Biol. 2017 Apr 3;216(4):961-981. doi: 10.1083/jcb.201611060. Epub 2017 Mar 20. PubMed
Site-specific recruitment of epigenetic factors with a modular CRISPR/Cas system.
Anton T and Bultmann S (2017).
Nucleus, 8, 279-286. PubMed
A Simple and Sensitive High-Content Assay for the Characterization of Antiproliferative Therapeutic Antibodies.
Stengl A, Hörl D, Leonhardt H and Helma J (2017).
SLAS Discov., 22, 309-315. PubMed
Visualization of Genomic Loci in Living Cells with a Fluorescent CRISPR/Cas9 System.
Anton T, Leonhardt H and Markaki Y (2017).
Methods Mol Biol., 1411, 407-17. PubMed
Proximity-triggered covalent stabilization of low affinity protein complexes in vitro and in vivo.
M. Cigler, T.G. Müller, D. Horn-Ghetko, M.K. von Wrisberg, M. Fottner, R. S. Goody, A. Itzen, M.P. Müller and K. Lang.
Angew. Chem. Int. Ed. 2017, doi: 10.1002/anie.201706927. PubMed
Tetrazines in Inverse-Electron-Demand Diels–Alder Cycloadditions and Their Use in Biology.
S. Mayer and K. Lang
Synthesis 2017, 49, 830. PubMed
2016
The cryo-EM structure of a ribosome-Ski2-Ski3-Ski8 helicase complex.
Schmidt C, Kowalinski E, Shanmuganathan V, Defenouillère Q, Braunger K, Heuer A, Pech M, Namane A, Berninghausen O, Fromont-Racine M, Jacquier A, Conti E, Becker T, Beckmann R.
Science. 2016 Dec 16;354(6318):1431-1433. PubMed
Structural basis for ArfA-RF2-mediated translation termination on mRNAs lacking stop codons.
Huter P, Müller C, Beckert B, Arenz S, Berninghausen O, Beckmann R, Wilson DN.
Nature. 2016 Dec 1. doi: 10.1038/nature20821. PubMed
Structure of the ribosome post-recycling complex probed by chemical cross-linking and mass spectrometry.
Kiosze-Becker K, Ori A, Gerovac M, Heuer A, Närenberg-Goloub E, Rashid UJ, Becker T, Beckmann R, Beck M, Tampé R.
Nat Commun. 2016 Nov 8;7:13248. doi: 10.1038/ncomms13248. PubMed
Recognition of the 3' splice site RNA by the U2AF heterodimer involves a dynamic population shift.
Voith von Voithenberg L, Sánchez-Rico C, Kang HS, Madl T, Zanier K, Barth A, Warner LR, Sattler M, Lamb DC.
Proc Natl Acad Sci U S A. 2016 Oct 31. pii: 201605873. PubMed
Rational design of cyclic peptide inhibitors of U2AF homology motif (UHM) domains to modulate pre-mRNA splicing.
Jagtap PK, Garg D, Kapp TG, Will CL, Demmer O, Luhrmann R, Kessler H, Sattler M.
J Med Chem. 2016 Oct 18. PubMed
Determination of local chromatin composition by CasID.
Schmidtmann E, Anton T, Rombaut P, Herzog F, Leonhardt H.
Nucleus. 2016 Sep 27:1-9. PubMed
Impact of Heterogeneity and Lattice Bond Strength on DNA Triangle Crystal Growth.
Stahl E, Praetorius F, de Oliveira Mann CC, Hopfner KP, Dietz H.
ACS Nano. 2016 Sep 7. PubMed
Insights from biochemical reconstitution into the architecture of human kinetochores.
Weir JR, Faesen AC, Klare K, Petrovic A, Basilico F, Fischböck J, Pentakota S, Keller J, Pesenti ME, Pan D, Vogt D, Wohlgemuth S, Herzog F, Musacchio A.
Nature. 2016 Sep 8;537(7619):249-253. doi: 10.1038/nature19333. Epub 2016 Aug 31. PubMed
Topology and structure of an engineered human cohesin complex bound to Pds5B.
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2015
Structure of the hypusinylated eukaryotic translation factor eIF-5A bound to the ribosome.
Schmidt C, Becker T, Heuer A, Braunger K, Shanmuganathan V, Pech M, Berninghausen O, Wilson DN, Beckmann R. Nucleic Acids Res. 2015 Dec 28. pii: gkv1517. PubMed
Architecture of the Rix1-Rea1 checkpoint machinery during pre-60S-ribosome remodeling.
Barrio-Garcia C, Thoms M, Flemming D, Kater L, Berninghausen O, Baßler J, Beckmann R, Hurt E.
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ATP hydrolysis by the viral RNA sensor RIG-I prevents unintentional recognition of self-RNA.
Lässig C, Matheisl S, Sparrer KM, de Oliveira Mann CC, Moldt M, Patel JR, Goldeck M, Hartmann G, García-Sastre A, Hornung V, Conzelmann KK, Beckmann R, Hopfner KP.
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Structural insights into the cooperative remodeling of membranes by amphiphysin/BIN1.
Adam J, Basnet N, Mizuno N.
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Structure of Ctk3, a subunit of the RNA polymerase II CTD kinase complex, reveals a noncanonical CTD-interacting domain fold.
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A modular open platform for systematic functional studies under physiological conditions
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Structure of the native Sec61 protein-conducting channel.
Pfeffer S, Burbaum L, Unverdorben P, Pech M, Chen Y, Zimmermann R, Beckmann R, Förster F.
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Structural disorder and its role in proteasomal degradation.
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Structural basis for recognition and remodeling of the TBP:DNA:NC2 complex by Mot1.
Butryn A, Schuller JM, Stoehr G, Runge-Wollmann P, Förster F, Auble DT, Hopfner K-P
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A network of assembly factors is involved in remodeling rRNA elements during preribosome maturation.
Baßler J, Paternoga H, Holdermann I, Thoms M, Granneman S, Barrio-Garcia C, Nyarko A, Lee W, Stier G, Clark SA, Schraivogel D, Kallas M, Beckmann R, Tollervey D, Barbar E, Sinning I, Hurt E.
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Structure of the catalytic domain of Mre11 from Chaetomium thermophilum.
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Structural analysis of the di-adenylate cyclase reaction of DNA-integrity scanning protein A (DisA) and its inhibition by 3'-dATP.
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Cryo-EM structure of the tetracycline resistance protein TetM in complex with a translating ribosome at 3.9-A resolution.
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Structural Basis for Dodecameric Assembly States and Conformational Plasticity of the Full-Length AAA+ ATPases Rvb1·Rvb2.
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Architecture of the RNA polymerase II-Mediator core initiation complex.
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2014
Structure of the Rad50 DNA double-strand break repair protein in complex with DNA.
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A network of assembly factors is involved in remodeling rRNA elements during preribosome maturation.
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Drug Sensing by the Ribosome Induces Translational Arrest via Active Site Perturbation.
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CCMpred--fast and precise prediction of protein residue-residue contacts from correlated mutations.
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Structure of the Rad50 DNA double-strand break repair protein in complex with DNA.
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Crystal and solution structure of the human RIG-I SF2 domain.
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Emerging mechanistic insights into AAA complexes regulating proteasomal degradation.
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Structural studies of DNA end detection and resection in homologous recombination.
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Conserved architecture of the core RNA polymerase II initiation complex.
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Chemical cross-linking/mass spectrometry targeting acidic residues in proteins and protein complexes.
Leitner A, Joachimiak LA, Unverdorben P, Walzthoeni T, Frydman J, Förster F, Aebersold R.
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Structure of the VipA/B Type VI Secretion Complex Suggests a Contraction-State-Specific Recycling Mechanism.
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Transient electrostatic interactions dominate the conformational equilibrium sampled by multidomain splicing factor U2AF65: a combined NMR and SAXS study.
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2013
Architecture of the Lsm1-7-Pat1 complex: a conserved assembly in eukaryotic mRNA turnover.
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Structure and subunit topology of the INO80 chromatin remodeler and its nucleosome complex.
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Unveiling the Long-Held Secrets of the 26S Proteasome.
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Structural analysis of the yeast Dhh1-Pat1 complex reveals how Dhh1 engages Pat1, Edc3 and RNA in mutually exclusive interactions.
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MuB is an AAA+ ATPase that forms helical filaments to control target selection for DNA transposition.
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cGAS produces a 2'-5'-linked cyclic dinucleotide second messenger that activates STING.
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Fast and accurate reference-free alignment of subtomograms.
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Structural mechanism of cytosolic DNA sensing by cGAS.
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Structure and function of the initially transcribing RNA polymerase II-TFIIB complex.
Sainsbury S, Niesser J, Cramer P.
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2012
Structure of Actin-related protein 8 and its contribution to nucleosome binding.
Gerhold CB, Winkler DD, Lakomek K, Seifert FU, Fenn S, Kessler B, Witte G, Luger K, Hopfner KP.
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Near-atomic resolution structural model of the yeast 26S proteasome.
Beck F*, Unverdorben P*, Bohn S, Schweitzer A, Pfeifer G, Sakata E, Nickell S, Plitzko JM, Villa E, Baumeister W, Förster F. *contributed equally
PNAS 2012 September 11. doi: 10.1073/pnas.1213333109. PubMed